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Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 126  

Gangrene in malaria revisited

Department of Neurology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India

Date of Web Publication27-Dec-2018

Correspondence Address:
Dr. Khichar Purnaram Shubhakaran
House No. E-22/9, Umaid Hospital Campus, Geeta Bhawan Road, Jodhpur- 342 001, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tp.TP_77_15

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How to cite this article:
Shubhakaran KP. Gangrene in malaria revisited. Trop Parasitol 2018;8:126

How to cite this URL:
Shubhakaran KP. Gangrene in malaria revisited. Trop Parasitol [serial online] 2018 [cited 2023 Mar 25];8:126. Available from: https://www.tropicalparasitology.org/text.asp?2018/8/2/126/248694


I read an interesting case report of Plasmodium falciparum malaria complicated by/disseminated intravascular coagulation, severe normocytic normochromic anemia, and symmetrical peripheral gangrene.[1] With the reemergence of malaria, such rare but unique complications of malaria have been observed from time to time and reported mainly from India.[2],[3],[4],[5] A few such cases or complications are also reported in Plasmodium vivax[4] and mixed[5] malaria also. Exact pathogenesis could not be ascertained.[2] Microcirculatory block due to sludging of the parasitized erythrocytes in capillaries is a well-known factor in heavy P. falciparum parasitemia. The blockage of terminal arteries/arterioles could be the important reason for the gangrene. The vascular flow in the organs is disturbed by vascular collapse, thrombosis, infarction, and similar effects brought about by clumping together of parasitized cells. All these factors slow down the circulation and cause “sludging.” In a patient presenting with dry gangrene and fever, a possibility of P. falciparum must be kept in mind, not only in endemic areas but, also in nonendemic areas because of the resurgence of P. falciparum in the last few years.[2]

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   References Top

Rana A, Singh DP, Kaur G, Verma SK, Mahur H. Symmetrical peripheral gangrene: A rare complication of Plasmodium falciparu m malaria. Trop Parasitol 2015;5:130-2.  Back to cited text no. 1
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Kochar Shubhakaran DK, Kumawat B, Kochar SK. A patient with falciparum malaria and bilateral gangrene of the feet who developed arrhythmia/ventricular fibrillation after quinine therapy. QJM 1998;91:246.  Back to cited text no. 2
Arya TV, Singh SP, Singh DK. Bilateral foot gangrene occurring in falciparum malaria. JAPI 1990;38:30.  Back to cited text no. 3
Arora N, Gogna A, Kumar D, Puri K. Peripheral gangrene in Plasmodium vivax malaria: A rare manifestation. Trop Doct 2013;43:23-4.  Back to cited text no. 4
Agarwal A, Rastogi A, Tiwari D. Symmetrical peripheral gangrene with mixed malaria. Indian J Pediatr 2007;74:587-8.  Back to cited text no. 5


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