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Year : 2021  |  Volume : 11  |  Issue : 1  |  Page : 46-48

Pancytopenia with hemophagocytic lymphohistiocytosis in Plasmodium falciparum: A unusual presentation


1 Cell Biology Laboratory and Malaria Parasite Bank, ICMR-National Institute of Malaria Research, Ministry of Health and Family Welfare, New Delhi, India
2 Department of Microbiology, VMMC and Safdarjung Hospital, New Delhi, India
3 Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Shyam Sundar Meena
Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi - 110 029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tp.TP_34_20

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Hematological manifestations such as anemia and thrombocytopenia are known complications in malaria. Here, we report two cases presented as pancytopenia with hepatosplenomegaly and initial diagnosis kept as hematological malignancy like leukemia but later on its diagnosed as malaria-associated hemophagocytic lymphohistiocytosis which is a rare entity. The aim of this report is to draw the attention of physicians, especially in tropical countries such as India and Sub-Saharan nations to keep in mind this uncommon presentation of malaria, though the exact pathophysiological mechanism still remains obscure.


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