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 Table of Contents  
LETTERS TO EDITOR
Year : 2022  |  Volume : 12  |  Issue : 2  |  Page : 130  

Cysticercosis and co-incidence with COVID-19


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Parasitic Disease Research Center, Suranaree University of Technology, Nakhon Ratchasima, Thailand

Date of Submission01-Oct-2021
Date of Decision01-Nov-2021
Date of Acceptance31-Dec-2021
Date of Web Publication24-Nov-2022

Correspondence Address:
Rujittika Mungmunpuntipantip
Private Academic Consultant, Bangkok-103330
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tp.tp_86_21

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Cysticercosis and co-incidence with COVID-19. Trop Parasitol 2022;12:130

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Cysticercosis and co-incidence with COVID-19. Trop Parasitol [serial online] 2022 [cited 2022 Dec 7];12:130. Available from: https://www.tropicalparasitology.org/text.asp?2022/12/2/130/361959



Sir,

An interrelationship between parasitic infestation and COVID-19 is interesting. Some reports mention for possible counteracting action to COVID-19 in parasitic infestation.[1] In a recent report, Wolday et al. noted that “Parasite co-infection is associated with a reduced risk of severe COVID-19 in African patients.[1]” Despite COVID-19's extensive distribution, no endemic parasitic infection has yet been identified as co-infecting with COVID-19. A good example is opisthorchiasis.[2] Regarding opisthorchiasis and COVID-19, the possible specific counteracting biological process is proposed.[2]

Here, the authors would like to draw attention to another important parasitic infection that has never been reported for association with COVID-19. Based on our setting in Indochina, where cysticercosis is very common, the authors reappraise local data on COVID-19 case. The setting has been affected by COVID-19 since January 2020. Until present, there are more than 1.5 million COVID-19 infected cases. According to local protocol for management, routine chest X-ray investigation is done. Of interest, there has never observation on coincidence between cysticercosis and OVID-19. In this setting, the cysticercosis is prevalent. The prevalence of detection of cysticercosis in routine chest X-ray investigation is 0.1%.[3] Based on the data on the epidemiology of cysticercosis in this setting, it is likely that there should be a coincidence of COVID-19 and cysticercosis detected from chest X-ray, however, there is no observation on coincidence.

This leads to an interesting question whether cysticercosis has a pathophysiological process that can protect against COVID-19. A possible mechanism might be associated with CD4 + Foxp3+. Excretory secretory antigens from cysticercus can increase the CD4 + Foxp3 + and CD8 + Foxp3 + T-cell frequencies.[4] Stimulation of CD4 + Foxp3 + is proposed as a possible process for the treatment of COVID-19.[5]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Wolday D, Gebrecherkos T, Arefaine ZG, Kiros YK, Gebreegzabher A, Tasew G, et al. Effect of co-infection with intestinal parasites on COVID-19 severity: A prospective observational cohort study. EClinicalMedicine 2021;39:101054.  Back to cited text no. 1
    
2.
Mungmunpuntipantip R, Wiwanitkit V. Relationship between prevalence of opisthorchiasis and incidence of COVID-19: An observation. Turkiye Parazitol Derg 2021;45:230.  Back to cited text no. 2
    
3.
Wiwanitkit V. Subcutaneous cysticercosis identified in chest radiography. Indian J Med Res 2012;136:678.  Back to cited text no. 3
[PUBMED]  [Full text]  
4.
Fan X, Zhang Y, Ouyang R, Luo B, Li L, He W, et al. Cysticercus cellulosae regulates T-cell responses and interacts with the host immune system by excreting and secreting antigens. Front Cell Infect Microbiol 2021;11:728222.  Back to cited text no. 4
    
5.
Wang Y, Zheng J, Islam MS, Yang Y, Hu Y, Chen X. The role of CD4+FoxP3+regulatory T cells in the immunopathogenesis of COVID-19: Implications for treatment. Int J Biol Sci 2021;17:1507-20.  Back to cited text no. 5
    




 

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